In TS normal response inhibition performance as measured by a Go/Nogo task can be assumed. However, there might be neurophysiological abnormalities in TS possibly related to compensatory mechanisms to control for tics. Hence, further studies combining neuropsychological and neurophysiological methods (e.g. electroencephalography, fMRI) using the same strictly controlled design along…
CONCLUSION:
Caudate volumes in children with Tourette syndrome predict the severity of tic and obsessive–compulsive symptoms in early adulthood. This study provides compelling evidence that morphologic disturbances of the caudate nucleus within cortico-striatal-thalamo-cortical circuits are central to the persistence of both tics and obsessive–compulsive symptoms into adulthood.
CONCLUSION:
Eighty-five percent of subjects reported a reduction in tic symptoms during adolescence. Only increased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst-ever tic severity was 10.6 years. Forty-one percent of patients with TS reported at one time experiencing at least…
CONCLUSION:
The findings in this study have important implications for understanding the developmental trajectory of brain functioning in persons with Tourette’s syndrome. Taken together with a large body of evidence from other Tourette’s syndrome imaging studies, our observations are consistent with the hypothesis that disturbances in the maturation of...
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CONCLUSION:
These findings are consistent with the known plasticity of the dentate gyrus and with findings from previous imaging studies suggesting the presence of failed compensatory plasticity in adults with TS who have not experienced the usual decline in symptoms during adolescence.
CONCLUSION:
Our results give further evidence that the genetics of Gilles de la Tourette syndrome is complex and suggest that Gilles de la Tourette syndrome is not a unitary condition, thus confirming the results of earlier studies which have described several Gilles de la Tourette syndrome phenotypes. Although a genome…
CONCLUSION:
We did not find evidence for altered brain lateralization in boys with TS. In addition, individuals in the TS group were able to modulate their ear advantage through instruction-driven attentional shifting to the right side, and thus they did not evidence problems with executive functioning. Nevertheless, left ear performance…